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ABSTRACT
Beginning of 1990’s, Solid lipid nanoparticles were introduced as an alternative to polymeric nanoparticles, liposomes, emulsions. This paper reveals the production methods for SLN, drug incorporation, loading capacity, drug release, various surfactants, lipids and various route of administration potentiality. SLN dosage form establishing the usage of  solid lipid matrix materials as a lipid pellets for oral drug delivery systems. Rheological measurement revealed the increase in storage modulus and critical stress during storage at all temperatures. By using membrane contactor method the lipid phase is pressed, at a temperature above the melting point of the lipid through the membrane pores allowing the formation of small droplets. The structures of SLN based on glyceryl behenate and medium chain triglycerides were characterized by photon correlation spectroscopy (PCS) and laser diffraction (LD), field-flow fractionation (FFF) with multi-angle light scattering detection (MALS), and cryo transmission electron microscopy (cryo TEM).
Key words: Solid lipid nanoparticles, Controlled release, Particle size, Bio availability.

ABSTRACT
In more development countries incidence and mortality rate risen among population due to mushroom poisoning. Edible mushroom for cooking and medical purpose was practiced from olden days and the risk involved for mistaken identity of poison mushrooms possess toxins which are secondary metabolites produced in specific biochemical pathway. Injection of poisonous mushrooms will lead to organ failure even it causes death. We did a systematic review of the published articles on epidemiology; diagnostics and treatment of mushroom poisoning from various literatures are reviewed. This review results Amanita species was frequently occurred poisoning when compare other species. Majority of the fatal poisoning worldwide attributable to amanita phalloides appropriately named as death cap. Our review suggest that most of mushroom poisoning are reported in developed countries whereas, least percentage of mushroom poisoning reported in developing countries.
Key words: Amanita species, epidemiology, Galerina Species, and Mushroom poisoning.

ABSTRACT
The present study explores the protective effect of Pentoxifylline and L- carnitine on ECT induced retrograde amnesia. Adult male wistar rats received ECT once on alternate days for 2 weeks. Rats were administered pentoxifylline (50 mg/kg p.o) and L-Carnitine (60 mg/kg p.o) for 2 weeks. The spatial memory was assessed by Morris water maze, Passive avoidance test and the whole brain total acetylcholinesterase (AchE) was also estimated. The results of our study suggest that Pentoxifylline and L- carnitine significantly reversed the ECT induced spatial memory deficits and also inhibits the increase in AchE activity by ECT.
Key words: Pentoxifylline, L-carnitine, retrograde amnesia, Acetylcholinesterase, ECT.

ABSTRACT
Since the dawn of civilization, plants have been the basis of a medicine and a major resource for human health care for curative and palliative functions. Man in today times has always been in quest of that herb that heals the body and soothes the mind as stress has begun to become a part and parcel of modern day life. Medicinal plants have been used to treat such psychotropic and behavioural conditions as anxiety, depression, seizures, poor memory, dementia, insomnia and drug intoxication. There have been limited studies on herbs having antidepression property. The aim of this article is to review the medicinal plants having such components that help in treating stress, psychotropic and behavioural disorders. A number of species and genera have been identified that are in use for treating such ailments directly or indirectly. However, further studies need to be conducted to explore and provide scientific credence to the folklore traditional use of medicines that could become helpful in developing effective green remedies sans side effects.
Key words: Medicinal plants, Depression, Stress.

ABSTRACT
A simple, sensitive, rapid, robust and reproducible method for the determination of Lamivudine in bulk and pharmaceutical formulation (Tablets) was developed using reverse phase high performance liquid chromatographic method (RP-HPLC). The RP-HPLC analysis was performed isocratically on XTERRA C18 (4.6X150mm) , analytical column using a mobile phase consisting of methanol and water in the Ratio of 50:50v/v, with a flow rate of 0.6ml/min.The analyte was monitored with UV detector at 270 nm. The developed method Lamivudine elutes at a retention time of 3.05 min. The proposed method is having linearity in the concentration range from10 to50 μg/mL of Lamivudine. The present method was validated with respect to system suitability, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), ruggedness, robustness.The proposed method can be readily utilized for bulk drug and pharmaceutical formulations.
Key words: RP-HPLC, Method development and validation, Lamivudine, Xterra C18 column.

ABSTRACT
Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. It has been long-lasting and potentially debilitating toxicity which was manifested by reduced renal function. The objective of our study was to assess the renal functions in cancer patients.who is on cisplatin chemotherapy which was carried out in MGM hospital at Warangal over a period of 6 months from May 2010 to October 2010.The study consists of 28 Oral Cancer outpatients receiving cisplatin chemotherapy for a period of 6 months. Whereas, 24 (85.71%) patients were males and 4 (14.28%) patients were females. The most predominate age group was found to be 61-70yrs 41.7% and BMI shows that 46.3% of patients were weighing normally. Cancer of Palate (35.71%) was more common. Serum creatinine, BUN levels were found to be 94.25±42.95 in 1st month and 122.6±57.44 in 6th month and 32.89±11.3 in 1st month and 48.4± 15.21 in 6th month. Creatinine clearances were found to be 60.96± 16.93 at the start and 67.8± 19.3 at the end of therapy. In addition to that GFR were found to be 80.43±2.919 in the 1st month and 5.61± 2.666 in the 6th month. A positive correlation exists between rise in serum creatinine and reduced GFR which is statistically significant. Our study concludes that, there was a slight change in the renal functions with increase in serum creatinine, BUN levels, and imbalanced serum electrolytes. Proper hydration and co administration of electrolytes as a supportive care during therapy will reduce renal toxicity of cisplatin therapy.
Key words: Cisplatin, Renal toxicity, Oral cancer patients.

ABSTRACT
The objective of present study was to investigate the effect of ethanolic extract of roots of Oroxylum indicum against cisplatin-induced renal injury in male albino rats. Cisplatin (6mg/kg body wt i.p.) induced nephrotoxicity evidenced by significant increase in Blood Urea nitrogen, Serum Creatinine, Urinary Total Proteins, Lipid Per oxidation levels and decreased Creatinine Clearence level. On oral administration of ethanolic extract (200mg/kg; 400mg/kg body wt) for 3days starting one hr before cisplatin administration significantly reduced elevated levels of Blood Urea nitrogen, Serum Creatinine, Lipid Per oxidation, reduced the protein excretion and increased Creatinine Clearence level. Histological studies also substantiated the above results. The effect of ethanolic extract of roots of O. indicum was dose dependent.
Key words: Oroxylum indicum, Cisplatin, Lipid peroxidation, Nephroprotector activity.